Shantani
Advanced Chemical Proteomics Technology
The application of existing 'target deconvolution methods' for identifying the targets of small molecules results in a long list of potential drug targets with no clear identification of the right target candidate(s). Because validating a long list of potential drug targets is cost and time prohibitory, available target identification methods provide no direct value in making 'GO / NO GO’ decision for the candidate drugs in the pipeline.....Shantani's Solutions (Read Further)
Most widely used cell based assays to screen test-molecule inhibitors
against know protein targets either indirectly report target engagement
through reporter-based methods or depend on
test-molecule-target interaction data generated after cell-lysis. These
prevailing methods for test-molecule screening do not provide direct
'real-time' target engagement information and suffer from data artifacts
originating from cell-lysis procedures.....Shatani's
Solutions (Read Further)