Shantani
Advanced Cell Based Assays
Benefits to Drug Discovery Process / Customers
Reduction of Expenses and Cycle Time - By quantifying direct target engagement in physiologically relevant intact biological systems and by completely avoiding 'assay repetition exercises' routinely conducted to eliminate data artifact origniating from cell-lysis procedures
Information Multiplexing - Generating multiple information (IC50, Cell based Ki and cell penetrability of the compound) from the same assay
Differentiating Features
1) Assays providing direct measurement of target engagement in physiologically relevant biological systems
2) Fit-for-purpose assays custom designed for seamless integration into product development cycle
Existing Problem
Most widely used cell based assays to screen test-molecule inhibitors against know protein targets either indirectly report target engagement through reporter-based methods or depend on test-molecule-target interaction data generated after cell-lysis. These prevailing methods for test-molecule screening do not provide direct 'real-time' target engagement information and suffer from data artifacts originating from cell-lysis procedures.
Shantani's Solutions
Shantani's advanced assay technology specifically quantify the interaction of test molecule with its target protein in intact biological systems.